The SD locus and IC locus have an additive effect on each other. Dogs that have an improper coat/no furnishings also have a propensity to higher shedding. One copy of the SD variant increases shedding from relatively low to moderate and two copies of the variant results in an increase to relatively high shedding. The SD variant disrupts the structure of sebum and results in increased shedding for breeds that show variation at the SD locus.
CAVALIER KING CHARLES SPANIEL SHEDDING SKIN
The MC5R gene is expressed in the hair follicle glands that produce the oily, waxy substance called sebum that assists in lubrication, water repellency, and thermo-regulation of the skin and hair. However, the overall degree of shedding for a dog is dependent on a combination genes and a better understanding of a dog's degree of shedding currently comes from knowledge of a dog's genotypes at both the SD locus and IC (Improper Coat/Furnishings) locus. A DNA variant in the MC5R gene (SD) has been associated with higher shedding in various breeds. The SD Locus (Shedding) has been identified as one gene that can impact the degree of shedding in certain breeds of dog. This dog will pass on the sd allele to 100% of its offspring. However, the overall degree of shedding for this dog is dependent on the combination of this dog's genotypes at the SD and IC loci. This dog carries two copies of the sd allele which has been associated with lower shedding than SD/SD and sd/SD dogs. This dog will pass on the SD allele to 50% of its offspring and the sd allele to 50% of its offspring. This dog carries one copy of the sd allele and one copy of the SD allele which has been associated with moderate shedding compared to SD/SD and sd/sd dogs.
This dog will pass on SD to 100% of its offspring. This dog carries two copies of the SD Allele which has been associated with higher shedding than sd/SD and sd/sd dogs. The SD Locus (Shedding) trait test reliably determines if a dog has one of the following genotypes at the SD locus: SD/SD
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